Tumors of the head and neck represent 3.2 % of newly diagnosed cancers; both surgery and chemo-radiotherapy are valid treatment options for head and neck cancer. In many head and neck cancer patients, dysphagia, malnutrition and aspiration pneumonia are found and significantly impact on quality of life. Dysphagia is related to the tumor itself, or consequences of its treatment. A large number of surgical procedures, according to tumor site and extension, patient age, and general conditions, have been developed and are reviewed in this chapter. Swallowing disorders are related to both the surgical approach (open or endoscopic) and the tissue removed; while surgery for oral and oro-pharyngeal cancers mainly impact on oral control, oral peristalsis and mastication, partial laryngeal surgery interferes with airway protection mechanisms, and complete laryngeal removal may be complicated with hypopharyngeal strictures. Different chemo-radiotherapy protocols are available nowadays and are reviewed here; dysphagia may arise in the first two years or even many years afterwards and is mainly related to increased oro-pharyngeal transit time, reduced tongue and pharyngeal strength, restricted laryngeal and hyoid elevation, poor vestibule and true vocal fold closure and possibly abnormal upper esophageal sphincter function. The primary treatment goal of dysphagia in head and neck cancer patients is maintaining functional oral feeding and preventing aspiration and thoracic complications. All patients treated for a head and neck cancers should have access to a dysphagia specialist and to an instrumental investigation in order to establish adequate treatment.